Antiarrhythmic drug research
نویسندگان
چکیده
منابع مشابه
The antiarrhythmic drug BRL-32872.
BRL-32872 is a new antiarrhythmic drug with balanced class-III and class-IV actions as categorized by the Vaughan-Williams classification. BRL-32872 blocks the rapid component of the cardiac delayed rectifier potassium channel IK(r) (IC(50) = 28 nM) and its molecular correlate HERG ("Human-ether-a-go-go related gene," IC(50) of 19.8 nM in cell lines) at low concentrations. It also inhibits the ...
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Since Schaper and his coworkers1-3 reported an excellent coronary vasodilating action of lidofiazine, a drug originally prepared in Janssen Pharmaceutica Institute, on conscious dogs with a previously implanted electromagnetic flow meter, the antianginal effect of the drug has been clinically investigated in our own and other laboratories. Its usual dose is 90 or 120mg per day. Recently, we adm...
متن کاملAntiarrhythmic drug treatment: need for continuous vigilance.
Any physician treating cardiac arrhythmias should be aware of a possible worsening of the arrhythmia (so-called arrhythmogenesis) after the start of antiarrhythmic drug treatment. To facilitate the recognition of that complication the type and possible mechanisms of arrhythmogenesis are reviewed. Recognition also requires an understanding of (a) the time of appearance of arrhythmogenic effects ...
متن کاملAntiarrhythmic Drug Therapy for Recurrent Ventricular Tachycardia
We performed intracardiac electrophysiologic studies in 33 patients with recurrent ventricular tachycardia. Nineteen patients underwent one, 10 patients two, and four patients three serial electrophysiologic studies. Ventricular tachycardia was successfully induced in 83% of the patients, and pacing methods were successful in terminating tachycardia in 71% of the studies, although pacing-induce...
متن کاملOptimal antiarrhythmic drug therapy for electrical storm
Electrical storm, defined as 3 or more separate episodes of ventricular tachycardia or ventricular fibrillation within 24 hours, carries significant morbidity and mortality. These unstable ventricular arrhythmias have been described with a variety of conditions including ischemic heart disease, structural heart disease, and genetic conditions. While implantable cardioverter defibrillator implan...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2006
ISSN: 0007-1188
DOI: 10.1038/sj.bjp.0706500